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L-Glutamine Transporter (Glutamine Transporter)
- Target
- Glutamine Transporter
- Molecular classification
- Transporter, SLC1 family, SLC6 family, SLC7 family, SLC38 family
01
Overview
Amino acid transporters for L-glutamine are membrane proteins responsible for the uptake and exchange of glutamine across cellular membranes. Glutamine is a key amino acid involved in various metabolic processes, neurotransmission, cell growth, and nitrogen balance. Several transporter families, including SLC1, SLC6, SLC7, and SLC38, mediate glutamine transport via Na+-dependent symport or Na+-independent antiport mechanisms. Key transporters include ASCT2, SNAT1, SNAT2, and LAT1. These transporters play crucial roles in various tissues, including the brain, liver, placenta, and cancer cells. Glutamine transporter activity underpins neurotransmitter cycling, nitrogen metabolism, and cell growth/proliferation. Targeting these transporters may offer therapeutic benefit, particularly in cancer.
- Other names
- Glutamine transporterGlutamine permeaseASCT2 (SLC1A5)SNAT1 (SLC38A1)SNAT2 (SLC38A2)LAT1 (SLC7A5)System A amino acid transporterSystem N amino acid transporterSystem ASC amino acid transporterSystem L amino acid transporter
02
Mechanism of action
Inhibition of glutamine transport
03
Biological functions
Amino acid transportGlutamine uptakeGlutamine exchangeNeurotransmitter recyclingNitrogen metabolismCell growthCell proliferationAmmonia detoxification
04
Disease associations
CancerNeurological disordersMetabolic disorders
05
Safety considerations
Off-target effects on other amino acid transportDisruption of nitrogen balance
06
Biomarkers
ASCT2 expression in tumors
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