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Target intelligence / Profile preview
L-histidine decarboxylase (HDC)
- Target
- HDC
- Molecular classification
- Enzyme, Pyridoxal-5'-phosphate (PLP)-dependent decarboxylase
01
Overview
L-histidine decarboxylase (HDC) is an enzyme that catalyzes the decarboxylation of L-histidine to histamine. It is the sole enzyme responsible for histamine synthesis in mammals and plays a critical role in various physiological processes, including immune regulation, neurotransmission, and gastric acid secretion. HDC is expressed primarily in mast cells, neurons, and gastric enterochromaffin-like cells. Pharmacological targeting of HDC is of interest for treating allergic reactions, neurological disorders, and gastrointestinal disorders.
02
Mechanism of action
Inhibition of L-histidine decarboxylation, leading to reduced histamine production.
03
Biological functions
Histamine biosynthesisNeurotransmissionImmune response regulationGastric acid secretion
04
Disease associations
Allergic reactionsInflammationNeurological disordersGastrointestinal disordersCancer
05
Safety considerations
Potential for off-target effects due to structural similarity with other PLP-dependent decarboxylases.
06
Interacting drugs
Antihistamines
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