Target intelligence / Profile preview

L-lactate dehydrogenase (LDH)

Target: LDH
Molecular classification: Enzyme

Overview

L-lactate dehydrogenase (LDH) is an enzyme that catalyzes the interconversion of pyruvate and lactate, with concomitant interconversion of NADH and NAD+. It plays a crucial role in anaerobic glycolysis and is found in various tissues. Elevated serum LDH levels are indicative of tissue damage or disease states, including myocardial infarction, hemolytic anemia, cancers, and inflammatory diseases. LDHA, a subunit of LDH, is a therapeutic target in cancer due to its role in the Warburg effect.

Mechanism of action

Enzyme inhibition

Biological functions

Anaerobic glycolysisLactate shuttlingCellular metabolism

Disease associations

CancerMyocardial infarctionHemolytic anemiaInflammationARDSCOVID-19

Safety considerations

Non-specific marker of tissue damage

Biomarkers

Elevated serum LDH levels

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