Target intelligence / Profile preview

L-lactate dehydrogenase C chain (LDHC)

Target: LDHC
Molecular classification: Enzyme, Lactate Dehydrogenase

Overview

L-lactate dehydrogenase C chain (LDHC) is an enzyme primarily expressed in testicular tissue and plays a crucial role in energy metabolism, particularly in sperm motility and male fertility. It catalyzes the reversible conversion of L-lactate and NAD⁺ to pyruvate, NADH, and H⁺. Aberrant re-expression in various cancers makes it a potential anticancer target.

Mechanism of action

Inhibition of LDHC enzymatic activity

Biological functions

Energy metabolismSperm motilityCatalysis

Disease associations

CancerInfertility

Safety considerations

Potential off-target effects due to similarity with other LDH isoforms

Biomarkers

LDHC expression in tumor tissue

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