L-Methionine (also known as L-Met or H-Met-OH) (Met (or L-Met))

L-Methionine is an essential amino acid containing a sulfur-containing thioether side chain that plays critical roles in protein synthesis and cellular metabolism[3][7]. The compound functions as a primary methyl-group donor in metabolic pathways and serves as a biochemical precursor to L-cysteine and glutathione, contributing to antioxidant defense mechanisms[4][6]. In therapeutic applications, L-Methionine is used as a hepatoprotective agent, supporting liver function and preventing pathological fat accumulation, and serves as an antidote to acetaminophen (paracetamol) poisoning by supporting detoxification pathways[3][6]. The amino acid is also utilized as a urinary acidifier and chelating agent for heavy metals[6]. Unlike traditional drug targets such as receptors or enzymes, L-Methionine is administered directly as a nutraceutical and dietary supplement to support metabolic function and tissue repair[5][6].

Other names

MethionineH-L-MET-OHL-Met-OH(S)-2-Amino-4-(methylthio)butanoic acidMethylthiobutanenitrile acid

As a therapeutic agent (not a target), L-Methionine functions through: - Methyl group transfer in metabolic pathways[6] - Conversion to L-cysteine and subsequently to glutathione for antioxidant activity[4] - Support of hepatic detoxification pathways[3][6]