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Target intelligence / Profile preview
L-selectin (CD62L)
- Target
- CD62L
- Molecular classification
- Type-I transmembrane glycoprotein, Cell adhesion molecule, Lectin, Receptor
01
Overview
L-selectin, also known as CD62L, is a type-I transmembrane glycoprotein and cell adhesion molecule expressed on leukocytes. It plays a critical role in leukocyte trafficking, mediating the initial tethering and rolling of leukocytes on endothelial cells, facilitating their migration to sites of inflammation and injury. L-selectin is involved in both adhesive interactions and intracellular signaling, influencing integrin activation and chemotaxis. It is a therapeutic target for inflammatory and autoimmune diseases.
- Other names
- SELLLeukocyte-endothelial cell adhesion molecule 1 (LECAM-1)Lymphocyte-homing receptor
02
Mechanism of action
Induction of L-selectin shedding
03
Biological functions
Leukocyte adhesionLeukocyte rollingLeukocyte tetheringTransendothelial migrationSignal transductionImmune cell traffickingHomeostatic recirculation of lymphocytes
04
Disease associations
InflammationAutoimmune disordersChronic inflammatory diseasesTissue injury
05
Safety considerations
Potential for immunosuppressionRisk of infectionOff-target effects on immune cell function
06
Interacting drugs
Diclofenac
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