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Target intelligence / Profile preview
L-type Amino Acid Transporter (LAT)
- Target
- LAT
- Molecular classification
- Transporter, Amino Acid Transporter
01
Overview
The L-type amino acid transporter (LAT) family comprises several members (LAT1-LAT4) that mediate the sodium-independent transport of large neutral amino acids. LAT1 (SLC7A5) is the most well-studied member and forms a heterodimeric complex with 4F2hc/CD98. It is highly expressed at the blood-brain barrier, placenta, and in various cancers, playing a crucial role in supplying essential amino acids for cell growth and proliferation. It has clinical significance because its overexpression in tumors makes it a therapeutic target, and its presence at the BBB allows it to be exploited for drug delivery to the brain.
- Other names
- L-type amino acid transporter 1LAT1SLC7A5L-type amino acid transporter 2LAT2SLC7A8L-type amino acid transporter 3LAT3SLC43A1L-type amino acid transporter 4LAT4SLC43A2
02
Mechanism of action
Targeted inhibition of amino acid transport
03
Biological functions
Amino acid transportNutrient transportBrain homeostasismTORC1 signaling regulation
04
Disease associations
CancerNeurological disorders
05
Safety considerations
Off-target effects due to broad expression in normal tissues.Potential for drug resistance development.
06
Interacting drugs
L-DOPA
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