Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
L-type Amino Acid Transporter 3 (LAT3)
- Target
- LAT3
- Molecular classification
- Transporter, System L-type Na(+)-independent neutral amino acid transporter
01
Overview
L-type amino acid transporter 3 (LAT3) is a member of the system L family of Na(+)-independent neutral amino acid transporters. It mediates the facilitated diffusion of large neutral amino acids across cell membranes, including leucine, isoleucine, valine, phenylalanine, and methionine. LAT3 is expressed in various tissues and is often upregulated in cancers, where it contributes to tumor cell proliferation, migration, and invasion. It is considered a therapeutic target for anticancer therapies aiming to starve tumors by blocking nutrient uptake pathways.
- Other names
- Large neutral amino acids transporter small subunit 3SLC43A1
02
Mechanism of action
Inhibition of amino acid uptake
03
Biological functions
Amino acid transportProtein synthesisCellular growth and proliferationmTORC1 pathway activation
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects on normal cellsDevelopment of resistance
06
Biomarkers
LAT3 expression level in tumors
Beyond the preview
Go deeper on L-type Amino Acid Transporter 3 (LAT3).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on L-type Amino Acid Transporter 3 (LAT3).