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Target intelligence / Profile preview
L-type Calcium Channel Cav1.2 (Cav1.2)
- Target
- Cav1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
The L-type calcium channel, specifically the Cav1.2 subtype, is a voltage-gated ion channel that mediates the influx of Ca\(^{2+}\) ions into cells upon membrane depolarization. It plays a central role in excitation-contraction coupling in cardiac, skeletal, and smooth muscle tissues and is also involved in aldosterone secretion in endocrine cells. In the heart, Cav1.2 is the predominant L-type calcium channel expressed in ventricular myocytes.
- Other names
- CACH2CACN2CACNL1A1CCHL1A1
02
Mechanism of action
Antagonists/blockers stabilizing inactive or closed states of Cav channels
03
Biological functions
Excitation-contraction couplingNeurotransmitter releaseGene expression regulationCalcium signalingRegulation of cell divisionRegulation of cell death
04
Disease associations
Timothy syndromeBrugada syndrome type 3Long QT syndrome type 8Cardiac arrhythmiasHypertensionAngina pectoris
05
Safety considerations
Cardiac arrhythmiasHypotension
06
Interacting drugs
Nifedipine
2 more in the full profile.
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