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Target intelligence / Profile preview
L-type Calcium Channel Protein (LTCC)
- Target
- LTCC
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel
01
Overview
L-type calcium channels are voltage-gated calcium channels that mediate calcium influx into excitable cells upon membrane depolarization. They are crucial for muscle contraction, hormone secretion, neuronal signaling, and other calcium-dependent processes. They are composed of a pore-forming α1 subunit and auxiliary subunits (β, γ, α2δ). There are four main α1 subunit isoforms (CaV1.1, CaV1.2, CaV1.3, CaV1.4) encoded by CACNA1S, CACNA1C, CACNA1D, and CACNA1F genes, respectively, each with distinct tissue distributions and physiological roles. L-type calcium channels are important drug targets, particularly for antihypertensive agents like dihydropyridines.
- Other names
- Dihydropyridine receptorVoltage-gated calcium channel, L type
02
Mechanism of action
Blockage of calcium influx through L-type calcium channels
03
Biological functions
Muscle contraction couplingHormone secretionNeuronal signalingCalcium influxExcitation-contraction couplingAction potential regulationGene expression regulationSynaptic plasticity
04
Disease associations
Cardiovascular diseaseNeurological disordersHypertensionTimothy syndromeBrugada syndrome
05
Safety considerations
HypotensionBradycardiaCardiac arrhythmiasDrug interactions
06
Interacting drugs
Dihydropyridines (e.g., Nifedipine, Amlodipine)
2 more in the full profile.
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