Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
L-type calcium channel subunit alpha 1C (CaV1.2)
- Target
- CaV1.2
- Molecular classification
- Ion channel, Voltage-gated calcium channel, L-type calcium channel
01
Overview
The L-type calcium channel subunit alpha1C (CaV1.2) is the pore-forming subunit of voltage-dependent L-type calcium channels, encoded by the *CACNA1C* gene. It mediates calcium influx upon membrane depolarization and plays a crucial role in cardiac muscle contraction and other excitable tissues. Dysregulation is linked to various cardiac and neuropsychiatric disorders.
- Other names
- CACNA1CCACH2CACN2CACNL1A1CCHL1A1
02
Mechanism of action
Inhibition of L-type calcium channels
03
Biological functions
Voltage-dependent calcium influxExcitation-contraction couplingRegulation of secretionRegulation of gene transcription
04
Disease associations
Timothy SyndromeBrugada SyndromeCardiac ArrhythmiasBipolar disorderHypertension
05
Safety considerations
Cardiac dysfunctionHypotensionArrhythmias
06
Interacting drugs
Nifedipine
1 more in the full profile.
Beyond the preview
Go deeper on L-type calcium channel subunit alpha 1C (CaV1.2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on L-type calcium channel subunit alpha 1C (CaV1.2).