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Target intelligence / Profile preview
L-type Voltage-Operated Calcium Channel (L-type Ca²⁺ channels)
- Target
- L-type Ca²⁺ channels
- Molecular classification
- Ion channel, Voltage-gated ion channel, Calcium channel
01
Overview
L-type voltage-operated calcium channels (L-type Ca²⁺ channels) are a subtype of voltage-gated calcium channels (VGCCs) found in the membranes of excitable cells such as cardiac, skeletal, and smooth muscle cells, as well as neurons. They play a critical role in coupling membrane depolarization to cellular responses by mediating the influx of Ca²⁺ ions upon activation by strong depolarizations. They are composed of α1, α2δ, β, and γ subunits, with the α1 subunit forming the ion-conducting pore. Different α1 subunit isoforms (Cav1.1, Cav1.2, Cav1.3, Cav1.4) exist with distinct tissue distributions and physiological roles. They are major drug targets for treating cardiovascular diseases like hypertension and angina.
- Other names
- L-type calcium channelL-VGCCHigh-voltage activated calcium channel
02
Mechanism of action
Reduction of calcium entry into cells, decreasing contractility or excitability
03
Biological functions
Excitation-contraction couplingNeurotransmitter releaseHormone secretionGene expression regulationPacemaker activityVascular tone controlVision adaptation
04
Disease associations
Cardiac arrhythmiasHypertensionHeart failureEpilepsyNeurodegeneration
05
Interacting drugs
Nifedipine
2 more in the full profile.
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