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Target intelligence / Profile preview
L3MBTL histone methyl-lysine binding protein 2 (L3MBTL2)
- Target
- L3MBTL2
- Molecular classification
- Histone modification protein (methyl-lysine reader), Chromatin-binding protein, Polycomb group (PcG) protein
01
Overview
L3MBTL histone methyl-lysine binding protein 2 is a nuclear protein that binds methylated histone residues to regulate chromatin state and gene expression, particularly serving as a transcriptional repressor as part of PcG complexes. It plays key roles in developmental processes and stem cell biology. In disease, mutations or dysregulation of L3MBTL2 are associated with certain central nervous system tumors
- Other names
- Lethal(3)malignant brain tumor-like protein 2L3MBTL2Polycomb group protein L3MBTL2HGNC: 18594NCBI Gene: 83746UniProtKB: Q969R5
02
Mechanism of action
For methyl-lysine reader proteins, inhibition would disrupt recognition of methylated lysines on histones, leading to altered gene repression/activation, but mechanisms are not yet established for L3MBTL2 specifically
03
Biological functions
Transcriptional repression (via chromatin modification)Negative regulation of gene expressionStem cell differentiationStem cell proliferationEctoderm development
04
Disease associations
Cancer (Central Nervous System Tumor with BCOR internal tandem duplication, IDH-wildtype anaplastic astrocytoma)Potential roles in cell cycle dysregulation and tumorigenesis
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