L3MBTL histone methyl-lysine binding protein 4 (L3MBTL4)

**L3MBTL histone methyl-lysine binding protein 4 (L3MBTL4)** is a nuclear protein involved in chromatin organization and the negative regulation of DNA-templated transcription. It is considered a member of the Polycomb group (PcG) proteins, which are important for maintaining genes in a repressed state through chromatin modification. The gene encodes a protein of approximately 623 amino acids and is conserved across several species. L3MBTL4 has been proposed as a tumor suppressor on chromosome 18p, with gene deletion, mutation, or downregulation implicated in some cancers. It does not have known direct interacting drugs or established biomarker roles, and there are no notable safety or therapeutic concerns currently associated with direct targeting of this molecule[1][2][5][6].

Other names

Lethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L(3)mbt-like protein 4L3mbt-like 4FLJ35936HsT1031histone methyl-lysine binding protein