La-related protein 4 (LARP4)

La-related protein 4 (LARP4) is an RNA-binding protein and member of the La-related protein family. It contains a conserved La module—consisting of a La motif and an RNA recognition motif—that is capable of binding single-stranded poly(A) sequences at the 3' ends of mRNAs[1][2]. LARP4 interacts with poly(A)-binding protein (PABP) and participates in the regulation of mRNA stability, particularly by affecting the poly(A) tail length and protecting transcripts from deadenylation[1]. Overexpression of LARP4 increases mRNA stability, while depletion reduces translation and contributes to increased cell migration and invasion, especially in various cancer cell lines[2]. LARP4 mutations have been found in a broad range of cancers, with some mutations altering its RNA-binding properties or its regulatory capacity over cell morphology and motility[2]. It does not currently serve as a direct therapeutic target, but its role in controlling translation and cancer cell behavior makes it notable for molecular and cellular biology.

Other names

La ribonucleoprotein 4PP13296La ribonucleoprotein domain family member 4c-Mpl binding proteinLARP4A