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La ribonucleoprotein 1, translational regulator (LARP1)
- Target
- LARP1
- Molecular classification
- RNA-binding protein, Translational regulator, Post-transcriptional regulator
01
Overview
La ribonucleoprotein 1, translational regulator (LARP1) is an RNA-binding protein that plays a key role in post-transcriptional gene regulation, especially as a downstream effector of the mTORC1 signaling pathway. It binds to the 3' poly-A tails of mRNAs and the 5'-cap of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif—primarily genes encoding ribosomal proteins and factors involved in translation. LARP1 modulates translation by repressing or promoting ribosome recruitment to these mRNAs, thus influencing protein synthesis rates according to cellular growth signals and nutrient availability. It is expressed at low levels in most normal tissues but is highly upregulated in various cancers, and high expression correlates with poor prognosis. LARP1 also enhances the replication of dengue virus and may have roles in the cellular stress response.
- Other names
- La-related protein 1LARP1La ribonucleoprotein domain family member 1Lar1Lhp1
02
Mechanism of action
Inhibition or modulation of mTORC1 signaling leads to altered LARP1 phosphorylation and changes translational regulation. Drugs that target upstream pathways (mTOR inhibitors) may reduce LARP1-mediated translation repression of TOP mRNAs.
03
Biological functions
Regulation of translation, particularly of terminal oligopyrimidine motif (5'TOP) mRNAsmRNA stabilization and destabilizationRegulation of cell growth and proliferationInteraction with mTORC1 signaling pathwayRegulation of apoptosis
04
Disease associations
Cancer (such as ovarian, colorectal, prostate, non-small cell lung, hepatocellular, and cervical cancers)Infection (dengue virus, SARS-CoV-2)
05
Safety considerations
No direct safety concerns are currently attributed specifically to LARP1, but modulation may impact cell proliferation and apoptosis, leading to potential concerns in cancer or regenerative biology
06
Interacting drugs
None specifically listed in current search results; mTOR inhibitors (such as rapamycin/sirolimus or everolimus) indirectly affect LARP1 through pathway modulation
07
Biomarkers
LARP1 protein level (prognostic marker in various epithelial cancers)Expression of 5'TOP mRNAs (e.g., ribosomal proteins)
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