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Target intelligence / Profile preview
La ribonucleoprotein domain family member 1B (LARP1B)
- Target
- LARP1B
- Molecular classification
- RNA-binding protein, Translation regulator, Other (La-related protein family)
01
Overview
La ribonucleoprotein domain family member 1B (LARP1B) is a member of the La-related protein family of RNA-binding proteins, which are involved in various aspects of RNA metabolism. LARP1B shares significant sequence homology with LARP1, including the presence of a La domain, an RNA recognition motif, and a DM15 region. LARP1B has been implicated in the regulation of mRNA translation, impacting cell growth, differentiation, and proliferation[1][3]. Recent research suggests that circular RNA isoforms of the LARP1B gene (circ-LARP1B) act as regulators in cancer, specifically by sponging microRNAs to modulate oncogenic pathways, highlighting its emerging role in oncogenesis[3]. Detailed mechanistic roles of LARP1B in translation or disease remain less well studied than those of LARP1, but it is considered a potential therapeutic target due to its involvement in mRNA regulation and cancer biology.
- Other names
- La-related protein 1BLARP2FLJ10378DKFZp434K245DKFZp686E0316La ribonucleoprotein domain family member 2La-related protein 2
02
Mechanism of action
Not well established for LARP1B specifically; other family members modulate translation via cap-binding and displacement of eIF4E from mRNA[1][2].
03
Biological functions
Regulation of mRNA translationCell growthCell differentiationCell proliferationPotential roles in apoptosis, migration, and tumorigenesis
04
Disease associations
Cancer
05
Safety considerations
Not established; insufficient data on specific therapeutic challenges for LARP1B.
06
Biomarkers
circ-LARP1B may serve as a biomarker in certain cancers such as cutaneous squamous cell carcinoma[3].
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