La ribonucleoprotein domain family member 6 (LARP6) mRNA (LARP6 mRNA)

La ribonucleoprotein domain family member 6 (LARP6) mRNA is the transcript encoding the LARP6 protein, which acts as a critical regulator of type I and type III collagen synthesis (UniProt Q9BRX2). The LARP6 protein specifically binds to a conserved 5' stem-loop (5'SL) structure in the 5' untranslated region of collagen mRNAs, a process essential for their coordinated translation and the subsequent secretion of collagen fibrils (Stefanovic, B., 2013, PubMed 19106096). In various fibrotic conditions, including liver cirrhosis, pulmonary fibrosis, and systemic sclerosis, LARP6 expression is significantly upregulated, leading to the excessive deposition of extracellular matrix (PubMed 26451368). Therapeutic targeting of LARP6 mRNA using antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) aims to reduce LARP6 protein levels, thereby selectively inhibiting the production of fibrillar collagens without affecting other cellular processes. This strategy is currently being explored in preclinical models as a highly specific approach to treating fibrosis, though no such therapies have yet reached clinical approval. Potential challenges include ensuring targeted delivery to fibrotic tissues and avoiding the disruption of essential physiological collagen maintenance and wound healing.

Other names

ACHN mRNALa-related protein 6 mRNALARP6 transcript

Antisense-mediated degradation or RNA interference-mediated cleavage of the LARP6 transcript to prevent the translation of LARP6 protein, thereby disrupting the coordinated synthesis of fibrillar collagens.