Lactase-phlorizin hydrolase (None)

Lactase-phlorizin hydrolase (LPH) is a membrane-bound glycoprotein enzyme primarily found in the brush border of enterocytes in the small intestine. It plays a crucial role in carbohydrate digestion, particularly lactose, and also hydrolyzes certain glycosides such as phlorizin. Deficiency or malfunction results in primary or secondary lactose intolerance due to inability to digest dietary lactose. Polymorphisms leading to persistent expression allow continued milk digestion into adulthood—a trait selected for in some populations. Congenital mutations cause rare but severe forms of neonatal-onset malabsorption syndromes.

Other names

LactaseLPHLPH1Lactase-glycosylceramidase

LPH hydrolyzes lactose into D-glucose and D-galactose, and also hydrolyzes phlorizin and other β-glycosides.