Lactate dehydrogenase A pseudogene 1 (LDHAP1)

Lactate dehydrogenase A pseudogene 1 (LDHAP1) is a processed pseudogene found in the Homo sapiens genome and shares high sequence similarity with the lactate dehydrogenase A (LDHA) gene[6][2][7]. Unlike LDHA, LDHAP1 has lost the ability to code for a functional protein due to accumulated mutations such as premature stop codons and deletions[7]. As a pseudogene, LDHAP1 does not have a known biological function, is not implicated in any disease roles, and is not a target of therapeutic drugs. The existence of LDHAP1, and processed pseudogenes generally, reflects the evolutionary history of genome duplication and mutation rather than current cellular or physiological processes[8][2][7]. Key Notes: - LDHAP1 does not encode a functional enzyme and thus is not a receptor, transporter, or enzyme relevant as a drug target[2][7][8]. - Functionality and disease associations refer instead to the functional LDHA gene, not to its pseudogene copies[1][3][9][5]. - When seeking information about druggable targets or biological roles in lactate metabolism or cancer, refer to the functional “Lactate dehydrogenase A” (LDHA), not to LDHAP1.

Other names

LDH-A pseudogene 1LDHAP1