Lactate dehydrogenase A pseudogene 7 (LDHAP7)

Lactate dehydrogenase A pseudogene 7 (LDHAP7) is annotated in the human genome as a member of the pseudogene family relevant to lactate dehydrogenase A. Pseudogenes are genomic DNA sequences similar to normal genes but are nonfunctional; they typically arise from the duplication or retrotransposition of a gene and acquire mutations that prevent their translation into active proteins. LDHAP7 does not encode a functional enzyme, is not transcribed into a biologically active protein, and is not considered a candidate for drug targeting, disease modulation, or biomarker development. It should not be confused with active LDH isoforms (such as LDHA or LDHB), which are metabolic enzymes implicated in glycolysis and cancer biology[1][2]. Note: Sometimes pseudogenes can have regulatory roles (e.g., via non-coding RNA), but there is no published evidence supporting this for LDHAP7 specifically. The confusion may arise because LDHA (lactate dehydrogenase A) is a significant metabolic enzyme and a known drug target in oncology, but LDHAP7 is not involved in these processes. If your intent was to refer to the active enzyme, you should look up "Lactate dehydrogenase A" or "LDHA" rather than "LDHAP7"[1].

Other names

LDHA pseudogene 7LDHAP7

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