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Target intelligence / Profile preview
Lactate dehydrogenase C4 (LDHC)
- Target
- LDHC
- Molecular classification
- Enzyme, Cancer-Testis Antigen
01
Overview
Lactate dehydrogenase C4 (LDHC) is a unique isoenzyme of lactate dehydrogenase primarily expressed in mammalian testis and spermatozoa. It plays a critical role in energy metabolism, particularly in sperm function and male fertility, and has recently gained attention as a cancer-testis antigen (CTA) due to its aberrant expression in various cancers. Targeting/inhibiting *LDHC* sensitizes some tumors to DNA damage response therapies; ongoing research explores its value both diagnostically & therapeutically.
- Other names
- LDH-C4LDH-XLDHCLactate dehydrogenase C
02
Mechanism of action
LDHC inhibition
03
Biological functions
Sperm energy metabolismSperm capacitationFertilizationATP productionGlycolysisTumor growth
04
Disease associations
Male infertilityBreast cancerLung cancerRenal cell carcinomaHepatocellular carcinomaMelanomaCancer
05
Biomarkers
LDHC mRNALDHC protein
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