Lactiplantibacillus plantarum LP14 (LP14)

Lactiplantibacillus plantarum LP14 (formerly known as Lactobacillus plantarum strain No. 14) is a specific probiotic bacterial strain recognized for its metabolic and immunomodulatory properties. As a member of the lactic acid bacteria group, it is found in various fermented foods and the human gut, where it serves as a beneficial biotherapeutic agent rather than a traditional molecular target. LP14 is primarily investigated for its ability to reduce adiposity, decrease serum cholesterol levels, and improve insulin sensitivity by modulating host gene expression and signaling pathways, such as those involving leptin and lipogenesis. Additionally, it has demonstrated clinical potential in managing seasonal allergic diseases by shifting the systemic immune response toward a Th1 profile and suppressing eosinophil counts. While the strain is considered safe for general consumption, its therapeutic efficacy is strain-specific and its activity can be diminished by concurrent antibiotic treatment.

Other names

Lactobacillus plantarum strain No. 14Lactobacillus plantarum LP14L. plantarum LP14Lactiplantibacillus plantarum DSM 33401

LP14 acts as a probiotic agent that modulates host physiology by suppressing lipogenic gene expression in adipose tissue, lowering serum leptin levels, and inducing Th1-type cytokine production to balance the Th1/Th2 immune response.