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Target intelligence / Profile preview
Lactobacillus jensenii (L. jensenii)
- Target
- L. jensenii
- Molecular classification
- Bacterium, Gram-positive lactic acid bacteria
01
Overview
Lactobacillus jensenii is a Gram-positive, rod-shaped, facultatively anaerobic bacterium predominant in the vaginal microbial flora, accounting for up to 23% of vaginal lactobacilli in healthy women. It contributes significantly to the host’s defense by producing lactic acid, hydrogen peroxide (H₂O₂), and other antimicrobial compounds (such as bacteriocins), which help maintain a low vaginal pH and inhibit the colonization and growth of potential pathogens, including Gardnerella vaginalis and Escherichia coli. L. jensenii also exhibits immunomodulatory properties, including downregulation of pro-inflammatory pathways, suggesting probiotic potential for maintaining vaginal and potentially intestinal health. It is not a classical therapeutic target (such as a receptor or enzyme) but is of interest as a beneficial live biotherapeutic agent.
- Other names
- L. jensenii
02
Mechanism of action
Not applicable
03
Biological functions
Maintenance of acidic vaginal environment (by producing lactic acid and hydrogen peroxide)Inhibition of pathogenic bacteria (production of bacteriocin-like inhibitory substances, H₂O₂, and competition for nutrients)Modulation of immune responses (downregulation of proinflammatory signaling; induction of anti-inflammatory mediators)
04
Disease associations
Infection (protective against vaginal infections, especially bacterial vaginosis)Other (maintenance of healthy vaginal microbiota; involvement in host-microbe interactions)
05
Safety considerations
Generally considered safe as part of normal microflora and as a probioticResistance to certain antibiotics reported, but not considered a primary safety concern for therapeutic use
06
Biomarkers
Decreased abundance is associated with bacterial vaginosisIts presence is a positive marker for healthy vaginal microflora
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