Lactobacillus lactis BCMC 12451 (BCMC 12451)

Lactobacillus lactis BCMC 12451 is a specific probiotic strain of lactic acid bacteria that serves as a core component of multi-strain microbial cell preparations, such as Hexbio. It is a Gram-positive, non-pathogenic bacterium that is naturally occurring in the gastrointestinal tract and is utilized therapeutically to restore and maintain microbial balance. The strain functions by colonizing the intestinal mucosa, where it produces organic acids like lactic acid to lower local pH and secretes enzymes such as bile salt hydrolase to inhibit the growth of pathogenic species. Clinical research suggests its efficacy in managing a range of conditions, including chronic constipation, antibiotic-associated diarrhea, and irritable bowel syndrome, while emerging evidence points to potential benefits in metabolic health and immune regulation. As a live microorganism, its activity is sensitive to antibiotic treatment, which can reduce its population and therapeutic effectiveness.

Other names

Lactococcus lactis BCMC 12451BCMC 12451MCP BCMC 12451

Competitive exclusion of enteric pathogens for adhesion sites; production of lactic acid and short-chain fatty acids (SCFAs) to lower intestinal pH; induction of anti-inflammatory cytokines such as IL-10; enhancement of tight junction protein expression to improve intestinal barrier integrity; and secretion of bile salt hydrolase (BSH) to modulate bile acid metabolism.