Ladybird homeobox 1 (LBX1)

Ladybird homeobox 1 (LBX1) is a protein-coding gene encoding a transcription factor that was identified due to its homology to the Drosophila lady bird genes. It is essential for the migration of muscle precursor cells during development, the specification of dorsal muscle identities in the forelimb, and the development of GABAergic interneurons in the dorsal horn of the spinal cord. LBX1’s disruption can lead to congenital and musculoskeletal syndromes, most notably congenital central hypoventilation syndrome and Leri-Weill dyschondrosteosis. The gene is located at chromosome 10q24 and exhibits classic homeobox domain architecture involved in sequence-specific DNA binding and transcriptional regulation

Other names

LBX1HHPX-6HPX6homeoboxLadybird homeobox protein homolog 1Ladybird homeobox homolog 1Transcription factor LBX1Lady Bird-Like HomeoboxCCHS3transcription factor similar to D. melanogaster homeodomain protein lady bird late