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Target intelligence / Profile preview
LAGE-1a Antigen (LAGE-1a)
- Target
- LAGE-1a
- Molecular classification
- Cancer/testis antigen
01
Overview
LAGE-1a is an isoform of the LAGE-1 protein, a cancer/testis antigen (CTA) encoded by the CTAG2 gene. Its expression is normally restricted to the testis but is aberrantly activated in various cancers, making it a potential target for T cell-based immunotherapies. LAGE-1a expression is often correlated with NY-ESO-1 and is induced by DNA demethylation.
- Other names
- CTAG2Cancer/Testis Antigen 2LAGE-ILAGE-Ia
02
Mechanism of action
Target of T cell-based immunotherapies (e.g., vaccines, adoptive T cell transfer) aiming to induce an immune response against tumor cells expressing LAGE-1a.
03
Biological functions
Tumor-specific antigen presentationTarget for T cell-based immunotherapy
04
Disease associations
Cancer (Melanoma, Non-Small Cell Lung Carcinoma, Bladder Cancer, Prostate Cancer, Head and Neck Cancer)
05
Safety considerations
Potential for off-target effects in testis (due to normal expression)Risk of autoimmunity if immune response is not tightly controlled
06
Biomarkers
LAGE-1a expression levels in tumor tissueCorrelation with NY-ESO-1 expression
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