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Target intelligence / Profile preview
Lambda Light Chain (λ light chain)
- Target
- λ light chain
- Molecular classification
- Immunoglobulin, Light Chain, Antibody Component
01
Overview
The lambda light chain is one of the two types of immunoglobulin (antibody) light chains found in humans. Each antibody molecule consists of two identical heavy chains and two identical light chains, which are either both kappa or both lambda. The primary function of these light chains is to contribute to antigen recognition and binding as part of the antibody's variable region. Abnormal production or ratios can indicate plasma cell disorders such as multiple myeloma or AL amyloidosis. AL amyloidosis often involves overproduction and misfolding/aggregation of monoclonal lambda free light chains, leading to toxic amyloid fibril deposits in tissues.
- Other names
- Immunoglobulin Lambda Light ChainLambda chainIGLC
02
Biological functions
Antigen recognitionAntigen bindingImmune responseAntibody structureComplement activation (indirectly through antibody)
03
Disease associations
Multiple myelomaAL amyloidosisMonoclonal gammopathy of undetermined significance (MGUS)B-cell lymphomasKidney disease (light chain deposition disease)
04
Safety considerations
Overproduction can lead to kidney damageAmyloid fibril formation and deposition in tissues (AL amyloidosis)Potential for off-target effects in antibody-based therapies
05
Biomarkers
Serum free light chains (lambda)Urine Bence-Jones protein (lambda)Lambda/Kappa ratio (serum)Lambda light chain in tissue biopsy (AL amyloidosis)
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