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Target intelligence / Profile preview
Lambda Myeloma Antigen (LMA)
- Target
- LMA
- Molecular classification
- Cell surface protein/antigen
01
Overview
Lambda myeloma antigen (LMA) is a cell surface antigen specifically expressed on malignant plasma cells in multiple myeloma, particularly those producing lambda light chains. It is not found on normal B cells or non-malignant plasma cells, making it a highly selective marker and potential therapeutic target for certain subtypes of multiple myeloma.
02
Mechanism of action
Monoclonal antibody binds to LMA, selectively eliminating malignant lambda-expressing plasma cells.
03
Biological functions
Targeting malignant plasma cellsIdentification of lambda-restricted malignant clones
04
Disease associations
Multiple Myeloma
05
Safety considerations
Potential for off-target effects, though less likely than with broader targets like BCMA
06
Interacting drugs
LambdaMab
07
Biomarkers
Presence of LMA on malignant plasma cellsRatio of kappa and lambda light chains
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