Lamin A/C protein (Lamin A/C)

Lamin A/C protein is a structural protein encoded by the LMNA gene in humans, and consists of two major isoforms—lamin A and lamin C—produced via alternative splicing[1][5][8]. Lamin A/C is a type V intermediate filament protein and a critical component of the nuclear lamina, a dense protein meshwork underlying the inner nuclear membrane[1][2][5]. Lamin A/C proteins provide mechanical support to the nucleus, maintain nuclear shape, organize chromatin, and regulate gene expression[3][5][8]. These proteins also play key roles in signal transduction, mechanotransduction, DNA repair, and telomere maintenance[2][3][4]. Mutations or dysregulation of lamin A/C impair nuclear integrity and function, leading to a spectrum of genetic disorders collectively called laminopathies, which include muscular dystrophy, dilated cardiomyopathy, lipodystrophy, and Hutchinson–Gilford progeria syndrome[1][3][5]. Dysregulation of lamin A/C expression is implicated in various cancers and may affect tumor aggressiveness and prognosis[3]. While not a direct therapeutic target, altered lamin A/C levels have potential as biomarkers for certain cancers, such as prostate cancer, or as indicators in genetic disease diagnostics[3].

Other names

Lamin ALamin CLMNA proteinPrelamin-A/C