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Target intelligence / Profile preview
Lamin A (LMNA)
- Target
- LMNA
- Molecular classification
- Intermediate filament protein
01
Overview
Lamin A is a type of intermediate filament protein that is a major structural component of the nuclear lamina. It provides mechanical stability to the nucleus, is involved in maintaining cell shape, mechanosensing, chromosome organization, DNA replication, transcriptional regulation, genome stability, apoptosis regulation, and nucleo-cytoskeletal coupling. Mutations in LMNA can cause various diseases collectively termed "laminopathies."
- Other names
- Lamin A/CPrelamin ALamin A and C
02
Biological functions
Nuclear structure supportMechanotransductionGenome organizationChromatin organizationGene regulationNuclear envelope assembly/disassemblyPositioning of nuclear poresRegulation of DNA synthesisApoptosis controlCellular differentiation
03
Disease associations
Emery-Dreifuss muscular dystrophyDilated cardiomyopathyLaminopathies
04
Safety considerations
Mutations in LMNA can cause various diseasesCellular fragility, especially in muscle tissues
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