Lamin B2 (LMNB2)

Lamin B2 is a type V intermediate filament protein encoded by the LMNB2 gene. It is a major component of the nuclear lamina—a filamentous meshwork adjacent to the inner nuclear membrane—which confers structural stability to the nucleus and participates in chromatin organization and gene expression. Lamin B2 is essential for maintaining nuclear mechanics during development, especially neuronal migration and brain organogenesis. LMNB2 promotes cell cycle progression and proliferation, and its overexpression is implicated in several cancers, including triple-negative breast cancer and colorectal cancer. LMNB2 is also linked to rare genetic conditions such as progressive myoclonic epilepsy and microcephaly. While currently not directly targeted by approved drugs, LMNB2 represents an emerging therapeutic and biomarker target in oncology and neurodevelopmental research

Other names

Lamin B2LMNB2EPM9MCPH27epididymis secretory sperm binding proteinlamin B3LMN2

No mechanism established for clinical drugs targeting LMNB2 directly; experimental silencing approaches (e.g., shRNA, siRNA) decrease LMNB2 expression and suppress tumor proliferation/apoptosis in cancer models