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Target intelligence / Profile preview
Laminin (LN)
- Target
- LN
- Molecular classification
- Glycoprotein, Extracellular matrix protein
01
Overview
Laminins are a family of large, multidomain glycoproteins that are essential components of the extracellular matrix (ECM), particularly in basement membranes. They play critical roles in tissue architecture, cell adhesion, migration, differentiation, and signaling. They are heterotrimeric proteins composed of α, β, and γ chains, forming a cruciform structure. Laminins interact with cell surface receptors like integrins and dystroglycan to mediate cell adhesion and signaling. Defects in laminin genes can result in muscular dystrophies, junctional epidermolysis bullosa, and nephrotic syndrome.
- Other names
- LamininsLaminin-111Laminin-511
02
Mechanism of action
N/A
03
Biological functions
Structural supportCell adhesionCell migrationCell differentiationCell growthNeurite outgrowthSignalingTissue architecture
04
Disease associations
Muscular dystrophyJunctional epidermolysis bullosaNephrotic syndromeTumor metastasis
05
Safety considerations
Aberrant laminin expression or mutations can lead to severe diseases
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