Laminin-411 (LN-411)

Laminin-411 (formerly known as Laminin-8) is a heterotrimeric extracellular matrix glycoprotein composed of alpha-4, beta-1, and gamma-1 chains (LAMA4, LAMB1, and LAMC1). It is a fundamental component of the vascular basement membrane, where it supports endothelial cell adhesion, migration, and the maintenance of vessel wall integrity (Hall et al., 2022). Laminin-411 plays a pivotal role in the immune system by facilitating the extravasation of leukocytes, particularly TH17 cells, across the blood-brain barrier into the central nervous system, making it a key player in the pathogenesis of neuroinflammatory diseases such as multiple sclerosis (Flanagan et al., 2012). In oncology, it is associated with tumor progression and metastasis, as it serves as a ligand for receptors like integrin alpha-6-beta-1 and Melanoma Cell Adhesion Molecule (MCAM/CD146), promoting the migration of cancer cells (Matrix Biol., 2014). Therapeutic interest in Laminin-411 focuses on disrupting these interactions using decoy receptors like MCAM-Fc or monoclonal antibodies to inhibit inflammatory infiltration and tumor spread. Additionally, it is utilized in regenerative medicine to direct the differentiation of pluripotent stem cells into endothelial lineages (Hall et al., 2022).

Other names

Laminin-8LN411Laminin subunit alpha-4/beta-1/gamma-1Alpha4beta1gamma1 laminin

Inhibition of the interaction between Laminin-411 and its receptors, such as MCAM (CD146) and integrins (e.g., alpha-6-beta-1), to prevent leukocyte infiltration into the central nervous system and inhibit tumor cell migration and metastasis.