Laminin-411 messenger RNA (Laminin-411 mRNA)

Laminin-411 messenger RNA (mRNA) is the genetic template for the Laminin-411 protein, a heterotrimeric extracellular matrix component consisting of alpha-4, beta-1, and gamma-1 chains (UniProt: P50539, P07942, P11047). This specific laminin isoform is predominantly localized in the vascular basement membrane, where it facilitates endothelial cell adhesion, migration, and the structural integrity of blood vessels (Fujiwara et al., 2006, PubMed: 16530704). In pathological states such as glioblastoma multiforme, Laminin-411 is significantly upregulated, promoting tumor angiogenesis and the migration of malignant cells (Ljubimova et al., 2013, PubMed: 24138685). Targeting Laminin-411 mRNA using antisense oligonucleotides (ASOs) or RNA interference (RNAi) represents a therapeutic strategy to suppress the synthesis of this protein, thereby inhibiting tumor growth and vascularization (Ding et al., 2010, PubMed: 20439711). Experimental therapies have demonstrated that reducing Laminin-411 expression can normalize tumor vasculature and improve the delivery of other chemotherapeutic agents. However, challenges remain regarding the specific delivery of these RNA-based drugs to the central nervous system and potential effects on normal vascular function.

Other names

LAMA4 mRNALaminin-8 mRNALaminin alpha-4 mRNALaminin subunit alpha-4 mRNA

Antisense inhibition or RNA interference-mediated degradation of mRNA to prevent the synthesis of the Laminin-411 protein complex