Laminin subunit alpha-3 (LAMA3)

Laminin subunit alpha-3 is an essential extracellular matrix glycoprotein encoded by the LAMA3 gene, primarily functioning as the alpha chain of laminin-332 (formerly known as laminin-5)[1][5][7]. Laminins are heterotrimeric proteins (alpha, beta, gamma subunits) fundamental to the structural integrity and function of basement membranes across many tissues, particularly the skin, where they contribute to strength, resilience, and cell-matrix adhesion[3][5]. Multiple transcript variants of LAMA3 generate different isoforms involved in cell adhesion, migration, proliferation, basement membrane assembly, and wound healing[1][3]. Mutations in LAMA3 cause severe genetic blistering diseases such as junctional epidermolysis bullosa and have been implicated in cancer development and progression, being variably up- or down-regulated in different tumor types[2][5]. LAMA3 interacts with other laminin subunits (gamma-2 and beta-3) and cellular integrins, playing a central role in epithelial homeostasis and tissue repair[4][3]. Dysregulation of LAMA3 is implicated in both inherited skin fragility disorders and as a biomarker for prognosis and therapeutic targeting in cancer[2].

Other names

Laminin subunit alpha-3LAMA3LAMNAE170nicein-150kDakalinin-165kDaBM600-150kDaepiligrinEpiligrin 170 kDa subunitEpiligrin subunit alphaKalinin subunit alphaLaminin-5 subunit alphaLaminin-6 subunit alphaLaminin-7 subunit alphaNicein subunit alphaBM600JEB2AJEB2BJEB2CLOCSBM600 150kD subunitLAM3alpha-3 subunitepiligrin 170 kda subunitepiligrin alpha 3 subunitkalinin 165kD subunitkalinin subunit alphalaminin 5, alpha-3 subunitlaminin A3laminin, alpha 3 (nicein (150kD), kalinin (165kD), BM600 (150kD), epilegrin)laminin-5 alpha 3 chainlaminin-5 subunit alphalaminin-6 subunit alphalaminin-7 subunit alphanicein 150kD subunitnicein subunit alpha

Not applicable (no direct drugs); conceptually, inhibitors or modulators would affect cell adhesion, ECM organization, or tumor cell motility/migration.