Laminin subunit alpha-5 (LAMA5)

Laminin subunit alpha-5 (LAMA5) is a large, multidomain glycoprotein that is a principal component of the extracellular matrix, specifically in basement membranes, and forms part of heterotrimeric laminin complexes (notably laminin-511, laminin-521, and laminin-523)[1][2][3][4]. It mediates essential functions in embryonic development, cell adhesion, migration, differentiation, and maintenance of tissue architecture, particularly in the brain, kidney, and other tissues[2][4]. Mutations in LAMA5 are linked to human diseases such as nephrotic syndrome type 26, bent bone dysplasia syndrome 2, and possibly epileptic and neurodevelopmental disorders[1][4]. LAMA5 interacts with integrins and other extracellular matrix proteins to regulate cellular signaling and synaptic stability[1][2][4][5]. There are currently no known drug-targeting mechanisms or directly interacting therapeutics.

Other names

Laminin subunit alpha-5LAMA5KIAA0533KIAA1907Laminin-10 subunit alphaLaminin-11 subunit alphaLaminin-15 subunit alphalaminin alpha5-chainBBDS2NPHS26laminin subunit alpha-5laminin alpha-5 chainlaminin-10 subunit alphalaminin-11 subunit alphalaminin-15 subunit alpha