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Target intelligence / Profile preview
Langerhans Cell (LC)
- Target
- LC
- Molecular classification
- Tissue-Resident Macrophage, Antigen-Presenting Cell (APC), Immune Cell
01
Overview
Langerhans cells (LCs) are specialized tissue-resident immune cells primarily found in the skin and mucosa. They function as antigen-presenting cells, capturing and processing antigens to initiate adaptive immune responses. They are also involved in immune regulation and maintaining tissue homeostasis. LCs express CD1a, langerin (CD207), and S100 protein and contain Birbeck granules. A key disease association is Langerhans Cell Histiocytosis (LCH), characterized by abnormal proliferation of LC-like cells, often driven by BRAF or MAP2K mutations.
- Other names
- Epidermal Dendritic Cell
02
Mechanism of action
Vemurafenib and dabrafenib inhibit BRAF V600E mutated kinases. Trametinib and cobimetinib inhibit MAP2K mutated kinases.
03
Biological functions
Antigen presentationImmune surveillanceImmune regulationTolerance inductionPhagocytosisHomeostasis
04
Disease associations
Langerhans Cell Histiocytosis (LCH)Skin InflammationInfectionAutoimmunity
05
Safety considerations
Potential for immune-related adverse events due to immune activation.Increased risk of infection with immunosuppressive therapies.Drug toxicities associated with BRAF/MAP2K inhibitors in LCH (e.g., skin toxicities, secondary malignancies).
06
Interacting drugs
BRAF inhibitors (e.g., Vemurafenib, Dabrafenib - in LCH)
3 more in the full profile.
07
Biomarkers
CD1aLangerin (CD207)S100 proteinBRAF V600E mutation (in LCH)MAP2K mutation (in LCH)
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