Langerin (CD207)

Langerin (CD207) is a type II transmembrane protein expressed primarily on Langerhans cells—a dendritic cell subset found in the skin and mucosal tissues. It is part of the C-type lectin receptor family and features a carbohydrate recognition domain that binds high mannose oligosaccharides and other glycans, facilitating the pathogen recognition and uptake necessary for antigen processing and presentation. Langerin’s ability to internalize antigens drives the formation of Birbeck granules, specialized organelles unique to Langerhans cells. Functionally, it acts both as an innate antiviral receptor (notably protecting against HIV-1 by capturing and degrading the virus) and as a mediator of adaptive immunity, presenting processed antigens to T cells. Besides defending against pathogens, Langerin expression is implicated in immune tolerance, tumor immunity, and the regulation of skin inflammation. Gene polymorphisms affecting the ligand binding of Langerin may influence infectious disease susceptibility and immune function. If additional specification is needed (e.g., species or isoform), refer to "CD207" in humans.

Other names

CD207C-type lectin domain family 4 member KLangerhans cell-specific antigenLangerhans cell antigen

Antigen delivery and presentation (candidate vaccines or experimental conjugates targeting Langerin to enhance adaptive immunity); Pathogen uptake/clearance through receptor-mediated endocytosis