Target intelligence / Profile preview

Lanosterol Synthase (LSS)

Target: LSS
Molecular classification: Enzyme, Isomerase

Overview

Lanosterol synthase is a key enzyme in the cholesterol biosynthesis pathway, catalyzing the cyclization of (S)-2,3-epoxysqualene to lanosterol. Lanosterol is a crucial precursor for cholesterol and all major steroid hormones. It is a therapeutic target for managing cholesterol levels and related metabolic disorders.

Other names: OSCOxidosqualene-lanosterol cyclaseOxidosqualene-cyclaseSqualene-hopene cyclase homolog

Mechanism of action

Enzyme inhibition

Biological functions

Steroid biosynthesisCholesterol biosynthesisLanosterol production

Disease associations

Metabolic disordersCardiovascular diseaseOther

Safety considerations

Potential impact on steroid hormone balanceOff-target effects on related enzymes

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