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Target intelligence / Profile preview
Lanthionine Synthetase C-like Protein Family (LanCL)
- Target
- LanCL
- Molecular classification
- Enzyme (structurally related to lanthionine cyclases), Signaling protein, Glutathione-binding protein
01
Overview
The lanthionine synthetase C-like (LanCL) protein family in eukaryotes is homologous to the prokaryotic LanC enzymes, which are involved in lantibiotic biosynthesis. In humans, three main members have been identified: LanCL1, LanCL2, and LanCL3. While their precise biochemical functions remain incompletely understood, these proteins are increasingly recognized for their roles in cellular signaling and regulation, particularly in Akt/mTOR pathways and antioxidant responses. Abscisic acid (ABA) has been identified as a ligand for LANCL2, opening potential therapeutic avenues.
- Other names
- LanCL1LanCL2LanCL3
02
Mechanism of action
Modulation of Akt/mTOR signaling pathway; modulation of CBS activity; binding to glutathione
03
Biological functions
Signal transductionAkt activationmTORC2 regulationAntioxidant responseGlutathione bindingCellular differentiationCell survivalRegulation of sulfur amino acid metabolism
04
Disease associations
Cancer (tumor initiation, survival signaling)NeuroprotectionMetabolic diseaseInflammation
05
Safety considerations
Incompletely understood biochemical functionsPotential for off-target effects due to structural similarities with bacterial enzymes
06
Interacting drugs
Abscisic Acid (ABA)
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