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Target intelligence / Profile preview
Large-Conductance Calcium-Activated Potassium Channel (BK channel)
- Target
- BK channel
- Molecular classification
- Ion channel, Potassium channel
01
Overview
The BK channel is a large-conductance potassium ion channel that is activated by both membrane depolarization and increases in intracellular calcium or magnesium levels. It plays a critical role in regulating membrane potential and cellular excitability across various tissues, including neurons, smooth muscle cells, endocrine cells, and even within organelles such as mitochondria.
- Other names
- Maxi-KSlo1KCa1.1KCNMA1
02
Mechanism of action
Activators for neuroprotection/cardioprotection; blockers for overactive bladder or certain forms of epilepsy
03
Biological functions
Membrane repolarizationRegulation of neurotransmitter releaseRegulation of smooth muscle toneModulation of hormone secretionCochlear hair cell tuningInnate immunity responses
04
Disease associations
Neurological disordersHypertensionAsthmaBladder dysfunctions
05
Safety considerations
Complex regulation mechanisms involving multiple auxiliary subunits making it difficult to target specificallyPotential for off-target effects due to widespread tissue distribution
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