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Large-Conductance Calcium-Activated Potassium Channel Alpha Subunit (BK channel alpha subunit)
- Target
- BK channel alpha subunit
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
The large-conductance calcium- and voltage-activated potassium (BK) channel alpha subunit forms the functional core of the BK channel, assembling as a tetramer to create the ion-conducting pore. BK channels are uniquely activated by both membrane depolarization and increases in intracellular Ca2+, allowing them to respond rapidly to changes in cellular activity. Upon activation, they permit rapid efflux of K+, leading to membrane hyperpolarization and decreased cellular excitability. Dysfunction or mutations can lead to disorders such as hypertension, hearing loss, and epilepsy. Pharmacological modulation is being explored for therapeutic purposes.
- Other names
- MaxiKKCa1.1Slo1Calcium-activated potassium channel subunit alpha-1
02
Mechanism of action
Activation of BK channels, leading to potassium efflux and membrane hyperpolarization.
03
Biological functions
Regulation of membrane potentialRegulation of vascular toneModulation of neuronal excitabilityRegulation of neurotransmitter releaseRegulation of action potential shapeAuditory hair cell tuningSmooth muscle regulationControl of cellular excitability
04
Disease associations
Arterial hypertensionHearing lossEpilepsyAtaxia
05
Safety considerations
Potential for altered vascular tonePotential for disrupted neuronal excitability
06
Interacting drugs
NS1619
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