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Target intelligence / Profile preview
Large conductance calcium-activated potassium channel subunit alpha-1 (KCNMA1)
- Target
- KCNMA1
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated potassium channel
01
Overview
The large conductance calcium-activated potassium channel subunit alpha-1 (KCNMA1) forms a potassium channel that is activated by both membrane depolarization and intracellular calcium. It plays a critical role in regulating neuronal excitability, smooth muscle contraction, and various other physiological processes. Modulation of KCNMA1 activity is a target for treating various neurological and cardiovascular disorders.
- Other names
- BKCa channelSlo1KCa1.1hSloMaxiK channel
02
Mechanism of action
Activation of BKCa channel leading to hyperpolarization and reduced neuronal firing
03
Biological functions
Regulation of neuronal excitabilityRegulation of smooth muscle toneRegulation of hormone secretionRegulation of blood pressureRegulation of neurotransmitter release
04
Disease associations
EpilepsyHypertensionAsthmaSchizophreniaSpinocerebellar ataxiaMuscle spasm
05
Safety considerations
HypotensionDrowsinessDizziness
06
Interacting drugs
Chlorzoxazone
4 more in the full profile.
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