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Target intelligence / Profile preview
Colonic Smooth Muscle (N/A)
- Target
- N/A
- Molecular classification
- Smooth Muscle Tissue, Contractile Tissue
01
Overview
Colonic smooth muscle refers to the specialized, involuntary muscle tissue found in the wall of the colon. It is essential for generating the contractile forces that drive colonic motility, enabling peristalsis and segmentation movements necessary for mixing and propelling luminal contents through the large intestine. Dysfunction contributes to symptoms like abdominal cramping, diarrhea, and constipation, common in disorders such as irritable bowel syndrome or inflammatory bowel diseases.
- Other names
- Large Intestine Smooth MuscleColonic SMCsColonic Muscularis Propria
02
Mechanism of action
N/A
03
Biological functions
Gastrointestinal MotilityPeristalsisSegmentationMixing of Luminal ContentsPropulsion of Luminal Contents
04
Disease associations
Irritable Bowel Syndrome (IBS)Inflammatory Bowel Disease (IBD)Crohn's DiseaseConstipationDiarrheaAbdominal Cramping
05
Safety considerations
Side effects of antimuscarinics (e.g., dry mouth, blurred vision)Side effects of prokinetic agents (e.g., cardiac arrhythmias with cisapride)Potential for altered contractility in disease statesMechanical stress induced suppression of contractility
06
Interacting drugs
Oxybutynin
4 more in the full profile.
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