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Target intelligence / Profile preview
Large Neutral Amino Acid Transporter Small Subunit 1 (LAT1)
- Target
- LAT1
- Molecular classification
- Transporter, Amino Acid Transporter
01
Overview
LAT1 (Large neutral amino acid transporter small subunit 1), also known as SLC7A5, is a sodium- and pH-independent transmembrane transporter responsible for the uptake of large neutral amino acids in exchange for intracellular amino acids. It forms a heterodimeric complex with CD98/4F2hc/SLC3A2 and is highly expressed in the blood-brain barrier, brain, placenta, activated T cells, and many cancer cells. LAT1 plays a crucial role in supplying essential amino acids to cells and serves as an entry route for drugs mimicking its natural substrates. Its role in tumor growth has made it an attractive target for anticancer therapies.
- Other names
- SLC7A5
02
Mechanism of action
Transport of large neutral amino acids across cell membranes, facilitating drug entry into cells.
03
Biological functions
Amino acid transportNutrient uptakeDrug transportCell growth
04
Disease associations
CancerNeurodegenerative disease
05
Safety considerations
Potential for off-target effects due to broad substrate specificityAltered amino acid homeostasis
06
Interacting drugs
L-Dopa
2 more in the full profile.
07
Biomarkers
LAT1 expression levels in tumor tissue
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