Large ribosomal subunit protein eL19 (RPL19)

Large ribosomal subunit protein eL19 (RPL19) is a cytosolic protein encoded by the RPL19 gene, forming part of the eukaryotic large (60S) ribosomal subunit and facilitating protein synthesis[2][3][5]. Besides its canonical structural role, RPL19 demonstrates extra-ribosomal functions relevant to cell cycle regulation, apoptosis under stress, and cancer biology[1]. Overexpression of RPL19 is observed in several malignancies, where it is linked to poorer prognosis, and its silencing reverts malignant phenotypes in vitro and in xenograft models[1]. Additionally, RPL19-derived peptides can act as tumor-associated antigens, eliciting cytotoxic T cell responses against cancer cells[1]. Thus, RPL19 is both a biomarker and a candidate therapeutic target in oncology.

Other names

Ribosomal protein L1960S ribosomal protein L19RL19_HUMANL19FLJ27452MGC71997DKFZp779D216eL19

Experimental: RNA interference (siRNA) silencing in cancer cells reduces malignancy and tumor growth.\nImmunotherapy: Antigenic peptide recognized by cytotoxic T cells, promoting immune destruction of cancer cells.\nStress modulation: Overexpression sensitizes cells to endoplasmic reticulum stress-induced apoptosis.