Large ribosomal subunit protein L27 (RPL27)

Large ribosomal subunit protein L27 (RPL27) is a structural protein of the 60S ribosomal subunit, encoded by the RPL27 gene. It plays a key role in ribosome assembly, rRNA processing, and protein synthesis, with critical functions in cell proliferation and survival. Beyond its canonical role, RPL27 is implicated in human disease: mutations lead to Diamond-Blackfan anemia, while overexpression supports proliferation and stemness of cancer cells in colorectal and liver cancer. While not currently targeted by approved drugs, RPL27's essential role in translation and emerging data on its extra-ribosomal functions make it a candidate for future therapeutic targeting in cancer and hematologic disorders

Other names

60S ribosomal protein L27Ribosomal protein L27eL27DBA16L27Large ribosomal subunit protein eL27

Experimental: - Downregulation or knockdown suppresses cell proliferation and induces apoptosis in cancer models (mechanisms involve downregulation of cell cycle proteins like PLK1 and increased pro-apoptotic markers like Bax and Caspase-3, decreased Bcl-2). - Therapeutic targeting would likely aim to inhibit its function to suppress cancer cell viability and stemness.