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Large ribosomal subunit protein mL62, mitochondrial (MRPL58)

Target: MRPL58
Molecular classification: Ribosomal protein, Peptidyl-tRNA hydrolase, Enzyme

Overview

Large ribosomal subunit protein mL62, mitochondrial (MRPL58) is an essential component of the mitochondrial large ribosomal subunit, acting as a codon-independent translation release factor. It has lost stop codon specificity, which allows it to terminate mitochondrial translation in cases of abortive elongation. This protein functions as a peptidyl-tRNA hydrolase, hydrolyzing prematurely terminated peptidyl-tRNAs and recycling stalled mitochondrial ribosomes. It is essential for maintaining mitochondrial protein synthesis and overall mitochondrial function.

Other names: MRPL58ICT1MRP-L58mL62DS-1DS139S ribosomal protein L58, mitochondrialDigestion substraction 1Immature colon carcinoma transcript 1 proteinPeptidyl-tRNA hydrolase ICT1, mitochondrial

Biological functions

Mitochondrial translationPeptidyl-tRNA hydrolysisRibosome recyclingTranslation termination (in mitochondria, codon-independent)

Disease associations

Urethral calculusArthrogryposis, distal, type 4

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