Large ribosomal subunit protein uL1 (uL1)

Large ribosomal subunit protein uL1 is a highly conserved structural component of the large 60S/50S subunit of both prokaryotic and eukaryotic ribosomes. It binds directly to 23S rRNA within the so-called "L1 stalk," which is mobile within the assembled particle. This mobility allows it to participate actively in releasing deacylated tRNAs from the E site during translation termination or translocation steps. The human version is encoded by RPL10A; alternative names include NEDD6 and CSA19 among others. While not typically considered a classical drug target outside antibacterial therapy, it can be targeted by antibiotics such as clindamycin that exploit differences between bacterial and mammalian translational machinery for selective inhibition.[1][5][9]

Other names

60S ribosomal protein L10aRPL10ANEDD6CSA19Csa-19L10Aribosomal protein L10a[5]

Drugs like clindamycin inhibit bacterial translation by targeting the large ribosomal subunit—specifically interfering with peptide elongation or tRNA translocation at the E site where uL1 plays a role[1].