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Target intelligence / Profile preview
Large ribosomal subunit protein uL3 (uL3)
- Target
- uL3
- Molecular classification
- Ribosomal Protein, Pfam family: Ribosomal_L3 (PF00297)
01
Overview
Large ribosomal subunit protein uL3 (uL3, also known as RPL3 in humans) is a universally conserved component of the large ribosomal subunit. It plays a critical structural and functional role within the ribosome, responsible for protein synthesis. uL3 is essential for maintaining the architecture of the peptidyl transferase center (PTC), which catalyzes peptide bond formation. It binds directly to rRNA and helps organize the catalytic core of the ribosome. Mutations in uL3 can disrupt PTC structure and function. It participates broadly across cellular biology including ribosomal assembly, mRNA decay, and gene expression. A paralogue, RPL3L/uL3-like, exists that is specifically expressed in heart and skeletal muscle.
- Other names
- RPL3
02
Mechanism of action
Inhibition of peptidyl transferase activity (by drugs like anisomycin)
03
Biological functions
Structural constituent of cytoplasmic large ribosomal subunitTranslation initiation, elongation, terminationmRNA catabolic processRibosomal assemblyGene expression regulation
04
Disease associations
Cancer (indirectly)Viral transcription/translation processes
05
Interacting drugs
Anisomycin
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